Active Life: about 8-12 hours
Drug Class: Synthetic estrogen/HPTA stimulator (Oral)
Average Reported Dosage: Men 50-100 mg daily
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Low, seldom reported.
Strong gonadotropin stimulator/mild anti-estrogen
Medically, Clomid is mainly used to fight infertility.
How it works ;
Clomifene is the active substance in Clomid (Clomiphene Citrate).
This drug inhibits the action of estrogen by binding to hypothalamic receptors.
A bit like Nolvadex, it fights estrogen at receptor levels.
As an estrogen agonist, it helps fighting against side effects such as gynecomastia.
During a steroids cycle, this product can be used both in the due course of the cycle as well as a restarter of the Hypothalamic pituitary, with however a preference for that last characteristic.
You are no longer unaware that as a safety measure, your body stops natural Testosterone production during a cycle because of the extra external input.
As an estrogen inhibitor, it helps to boost androgen hormones production. And this, at the end of the cycle is what you need. Because as you know, after a cycle your androgen levels drop drastically you have to help your body restart its natural production.
Clomid also represses estrogen negative feedback, which stimulates HPTA (hypothalamic-pituitary-testicular-Axis),
This in turn stimulates LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone) which will stimulate the natural release of Testosterone.
As said, the use of this medicine is mostly appropriated at the end of the cycle.
How to use Clomiphene ?
This creates a signal to the leydig cells in the testes, which in turn produce more testosterone and sperm. Normally with Clomiphene this took 5-15 days. Most started with 50-mg twice daily for about 5 days, then reduced intake to 50 mg once a day for 5-10 more days. Due to Clomiphene providing a fast response time, I felt it was often beneficial to use a dosage of 100 mg total daily for 5 days, mid-cycle during longer AAS protocols. This drug was seldom utilized for longer than 15 days continuously simply due to it being unnecessary. The goal was to normalize testosterone production post AAS cycle as quickly as possible so as to minimize post-cycle strength and mass loss. Not create dependency.
HCG was combined with Clomiphene (Clomid) sometimes, or Clomiphene was used after HCG administration. This is because Clomiphene acts by affecting the hypothalamus and pituitary (hypophysis) and regenerating the whole regulating system, while HCG only "imitates" LH, thus stimulating the leydig cells in the testes to produce natural testosterone.
Side effects :
As for toxicity and side effects, Clomid is considered a very asfe drug. Bodybuilders seldom report any problems but listed possible side effects do include hot flashes, nausea, dizziness, headaches and temporarily blurred vision. Such side effects usually only appear in females however, as they feel the effects of oestrogen manipulation much more readily than men.